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Second, during the asexual stage, nuclei with a replication or a segregation advantage during spore formation can be selected.
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A large (∼200) collection of strains carrying a metabolic mutation and a replication or division Ts mutation (apart the spontaneously isolated strains) was generated by transforming Ts cells with total DNA extracted from strains containing a labeled metabolic mutation.
Furthermore, authors should state whether the report concerns the development of a novel risk model (and if so, whether some sort of internal or external validation is performed) or about a replication or validation of an earlier model.
For years, it was extremely difficult to publish a direct replication, or a failure to replicate an experiment, in a good journal.
This pathway allows a damaged chromosome to be repaired using a sister chromatid (available in G2 after DNA replication) or a homologous chromosome as a template.
Whether observed apoptotic cells were a direct result of the viral replication or a consequence of an overactivation of the immune system requires further studies.
If the causal SNP is poorly tagged by the associated SNP reported in the discovery population (European), the differences in LD between the north Indian and Dutch populations could result in either a lack of replication or a different localization of the association signal.
An E1/E3-doubly deleted replication-incompetent adenoviral vectors Ad-stTRAIL or Ad-flTRAIL was constructed through Cre-lox recombination as described [20].
Ophthalmic involvement may result from a direct viral replication or from an immune reaction to the systemic viral infection [8].
Although additional chromosomes minimally offer an additional replication origin, which could speed replication or facilitate a larger genome, a broader question remains: to what extent does selection act on bacterial genome organization?
Therefore, we investigated whether the heightened temperature sensitivity phenotype of cdc13-1 mrc1Δ mutant strains is a result of a replication defect, a checkpoint defect or both.
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