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A replication analysis was performed using part of International Multi-Center ADHD GenetIMAGEroject (IMAGE) dataset.
Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: a replication analysis of the Food and Drug Administration Database.
We then performed a replication analysis in the Harvard University Lung Cancer study (LCS) with 984 NSCLC patients.
Thirty-six candidate SNPs (P < 0.05) were assessed in a replication analysis consisting of three additional studies (n = 1,094 cases; n = 829 controls).In initial analysis, thirty-six SNPs were suggestive of association with risk of serous ovarian cancer, all subtypes of ovarian cancer, or both (P < 0.05).
One group had performed a replication analysis for their samples (GDS2106), which we used here as a fourth comparator being a technical replicate for the observations in GDS2106.
A replication analysis is planned before the official publication of these results.
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For the second stage, we performed a local replication analysis based on a 500 kb linkage disequilibrium (LD) block containing a query SNP determined by the SNPs most distant from the query SNP with r ≥ 0.3.
Finally, Athanasiu et al (2010) [22] performed a GWAS, an independent replication analysis of their top 1000 GWAS markers in another sample [38], and a combined analysis of the primary and replication samples.
We performed both an independent replication analysis and a combined analysis using the original De Jager et al. GWA sample set.
Next, in an independent case-control study of lymphoma, we performed a small replication analysis of associated SNPs that were chosen based on the criteria that multiple SNP-NHL associations were observed in the same gene or gene family.
We therefore conducted a comprehensive replication analysis in the largest study available to date using genotypes and imputed genotypes of SNPs located in or near these genes.
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