Here we describe the design, synthesis and structure activity relationships of a series of benzimidazole-based compounds with activity against Mycobacterium tuberculosis (Mtb) in a replicating state, a physiologically-induced non-replicating state, or both.
Though no systems behaved as a replicator, some possessed collections of properties from which a replicating system might theoretically be constructed without requiring the introduction of additional classes of properties.
Because the nonreplicating assay is bacteriostatic and coupled to a replicating outgrowth stage to permit surviving cells to increase in biomass, a replicating-inactive drug must be nonreplicating-bactericidal to give an NR-MIC90 (Fig. 1).
As power is a function of both the strength of the association (effect size) and the MAF of the associated variant, limitations in transethnic replicability of variants resulting from limited allelic polymorphisms in a replicating population is a notable challenge.
"There has to be a replicating effect of this training.
On occasion, in the course of the creation of an egg or sperm cell, a replicating Alu sequence will be inserted in the midst of a critical gene, resulting in a child with a genetic disease.
a The circular genome of a replicating Avidian individual.
It has been argued that within such a pool of random RNA molecules, at least some were bound to be catalytic, and a replicating RNA inside a lipid vesicle does in fact cause it to grow.
But the models also contain structural information such as information the DNA double helix topology and the movements undergone by a replicating DNA molecule (still hypothetical at that time).
The mechanism by which mycobacteria return to a replicating state upon re-exposure to favorable conditions is not understood.
The first vector, pA7248AMV-GFP [ 32], is a replicating system based on the PVX genome.
