The authors discuss how GxE interaction hypotheses can be tested with large and small samples, how GxE research can be carried out before as well as after replicated gene discovery, the uses of GxE research as a tool for gene discovery, the importance of construct validation in evaluating GxE research, and the contribution of GxE research to the public understanding of genetic science.
This case study illustrates a specific example of the benefits, and limitations, of semantically replicating data discovery.
Later experimenters could not replicate the discovery, and it was dismissed as an error for many years.
The results should be seen as a curiosity rather than a discovery until replicated and investigated further, Albertini said.
What really seemed to explain the silence on Monday night was the simple fact that Ms. Olsen has found her sound — her voice, alone and untreated and slow, conjoined with the specific resonance of her guitar — and she's able to replicate a private discovery in front of a crowd.
We identified 83 SNP-SNP models that replicated across the discovery and replication datasets.
Where other scientists can prove their theories and replicate their discoveries in petrie dishes and test tubes, sociologists are not so much discoverers as chroniclers of social phenomena.
10 P.M. (Discovery) KING OF THE GRILL This special follows Ritch Robin as he designs a grill replicating a space shuttle that shoots flames.
In two independent cohorts of schizophrenic individuals,that is, a discovery and a replicate sample, we identify a role of MECP2 in aggressive human behavior and show that a polymorphism in the untranslated region of the gene determines binding efficiency of another brain-expressed regulator, microRNA-511.
Roussos et al. (12) followed with their finding that the catechol- O-methyltransferase (COMT) Val158Met SNP affects PPI in healthy male volunteers, a discovery which we recently replicated in a mixed-sex sample of schizophrenia patients (13).
The only other reported biparental population and multisite apple QTL mapping experiment was carried out using 251 seedlings from a 'Fiesta' × 'Discovery' population replicated in three locations in Switzerland.
