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The present study was designed as a repeated dose 28-day oral toxicity study in rodent.
And maybe without realising that it's not a straightforward step to move from giving a single dose to giving a repeated dose," she explains.
To obtain more detailed information about the safety and immunogenic potential of the VN1203ΔNS1 virus, a repeated dose toxicity study was conducted in ferrets.
The patient was treated with 12 mg ivermectin once, with a repeated dose 2 weeks later.
ICL increased following the second and third doses in a repeated dose schedule.
If needed, a repeated dose of 120 μg/kg was given after 1 1.5 hours (36 patients).
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The impetus for this study was our clinical experience that, in some TN patients showing poor responses to BTX-A, repeated dosing may lead to better pain relief.
While a single dose of 5 μg zoledronic acid did not affect tumour burden in visceral organs, a repeated dosing regimen significantly reduced the number of metastatic foci in lung and liver.
Considering the profound vasoconstrictive effect of a single dose of IRL 1620 in tumours, further studies are warranted to determine its effects in a repeated dosing schedule on tumour angiogenesis and growth, where selectivity of vascular effect for tumours may not be critical.
Larval numbers were accurately estimated in the bulked aqueous suspension and administered to each restrained lamb with the use of a repeating dose syringe fitted with an oral dosing attachment designed for lambs.
Chondrocytes were stimulated with either a single dose of 10 or 100 ng/ml IL-1β or with a daily repeated dose of 10 ng/ml IL-1β.
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