Exact(9)
Issues in the Implementation of a Remote Memory Paging System.
We use hybrid address spaces for an implementation of MapReduce, a programming model for large-scale data processing, and the implementation of a remote memory access (RMA) model.
"We demonstrated that this pathway is crucial for the transformation of a recent memory, formed within a day, to a remote memory that still exists at least six weeks later," Tonegawa said.
Integrin β2−/− mice also showed a remote memory deficit.
Interestingly, although the Dab1p45/− mice showed a remote memory deficit in our population based comparison, there were no differences when compared to their littermate controls and therefore we did not pursue their study (Figure 3a).
Specifical alterations in 24-hour memory consolidated and remote memory were not tested however, based on a normal memory phenotype at seven days, which is it is indicative of protein-synthesis dependent memory and the transition to a remote memory [31], [32], we speculate that all three mutant strains will show relatively normal memory at these times as well.
Similar(51)
However, a test of remote memory, which was conducted at 45 days after the conditioning, showed a marked decrease of freezing rates when compared to their WT littermates (*p<0.001; Bonferroni corrected pair-wise comparisons), even though the Cdc42 cKO mice clearly were not impaired in the initial 4 days.
This 'graded retrograde amnesia' supports an idea that remote memory retrieval may be independent of hippocampal functions.
Instead the results of these tests show that during reversal learning loss of Cdc42 leads to a slight delay in long-term memory formation and a pervasive deficit in remote memory recall.
A specific deficit in remote memory is fascinating and future studies with these animals could significantly advance our understanding of the mechanisms of remote memory retention/retrieval.
Cdc42 cKO mice traveled significantly shorter distances (t(1,16) = 3.238, *p<0.01) and spent less time (t(1,16) = 3.208, *p<0.01) within the target quadrant compared to those of WT controls (independent t tests), again supporting a selective deficit in remote memory.
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