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Well, the reality of it is, when the disease is more active or when your symptoms are more active, I think that your answers would tend to be different than when you're in, and I won't say I'm in remission, because you don't have a remission with the disease.
Up to 70% of patients will achieve a remission with this protocol.
Noteworthy, none of our 12 patients with initially refractory disease reached a remission with second ICT.
Noteworthy, none of patients with initial non-responding disease reached a remission with second immunochemotherapy.
The major objective in the treatment of PRCA is to induce a remission with the recovery of erythropoiesis, thus providing relief from transfusions and avoiding transfusion-associated problems.
It is thought that the ATD therapy will influence the chances of remission, and/or the recurrent patients are unlikely to achieve a remission with a second course of ATD therapy, making radioiodine a better initial therapeutic choice.
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The clinical phase I trial of zosuquidar, co-administered with daunorubicin and cytosine arabinoside (ARA-C) on sixteen patients with AML [ 15] has shown that eleven patients achieved a complete remission and one a partial remission with a median survival of 559 (range 38 906) days.
One patient (2%) had a CR and 19 patients (31%) a partial remission, with an overall response rate of 33%.
Up to now 60 70% of AML patients reach a complete remission with a long-term survival of only 25 40%.
In the case of metastasis, few patients achieve a durable remission with currently available therapies, with a response rate of ∼15 25% and overall median survival of <12 months (Gupta et al, 2008; Motzer et al, 2013).
The biopsy was derived from a previously untreated patient who went on to show a complete remission with CDDP (Harrap et al, 1990).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com