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They suggested two criteria for a clinically relevant change: i) The magnitude of change between pre- and post-treatment scores should be statistically and reliably tested by use of a reliable change index (RCI).
All panels show a reliable change in long-range dependence over release years.
For the outcomes of neurocognitive scores and TSS, a reliable change was based on meaningful change at the 80% confidence interval level [44].
Apparently, then, even small doses of cocaine are associated with a reliable change in striatal dopaminergic functioning.
A reliable change in fitness or hormonal status may only be indicated by a substantial change in skin blood perfusion or oxygenation.
We found that ΔF/F>25%, corresponding to an increase an increase of [Ca2+]I of 164±7.5 nM, was necessary for inducing a reliable change in the AKAR 3 FRET ratio.
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The inhibitor of JNK did not show a statistically reliable change, indicating that JNK pathway might not control viral replication.
These are the first findings that identify a single reliable change in so many different cancers.
First, a statistically Reliable Change (RC) should exceed the change caused by chance fluctuations, denoted as the Smallest Detectable Difference [ 6, 7] (SDD; thus RC > SDD).
Also related to selecting items in an adaptive way, one might question whether statistically, an overall reliable change (RC > SDD for score means) can be achieved in patients with a low baseline, who have only reference items of '2' of which some scores decrease by merely one unit rather than consistently by two units.
An increasingly used technique is calculating a measure of reliable change, which takes into account the reliability of the measurement instrument and has been proposed to provide a more accurate standard of meaningful change [ 15, 16].
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