This proteolysis mechanism would likely also apply to VEGF bound to cell-surface HSPGs, which is a more relevant scenario for a tip cell lacking a basement membrane.
In vivo studies involved co-transplantation of OSCC cells with bone marrow stromal cells genetically modified to over express BMP-2, to mimic a clinically relevant scenario for regenerating bone using cell-based therapy in a wound containing microscopic residual disease.
Subsequently, we implanted the tumor cells first, labeling them in vivo, to represent a clinically relevant scenario.
Our simulation data suggest that a biological relevant scenario is established for values of half-lives of infected cells above 50 days or 20 days if the mean life-span of free virions will be over 32 hours.
Thus it turned out as relevant to focus the target search to a specific relevant scenario.
However, they validated their method in a more relevant scenario, showing that when the method is used to select decoys generated by ROSETTA (Das and Baker, 2008), there is a statistically significant enrichment in correct models.
It is a practically relevant scenario because patients generally seek medical help after the onset of symptoms, and in other patients treatment begins after a certain period of time required to confirm the exposure.
