Cryptorchidism is a relevant condition, with an estimated incidence in Italy of 3,5% yearly [ 2].
However, it may underestimate comorbidity as patients who suffer from a relevant condition but are treated entirely in primary care score zero.
Other strengths of this classification are that is has a clear hierarchical structure, is based on ICD codes, and enables 85% of stillbirth cases to be assigned a relevant condition.
They advocate the view that in a specific situation a causally relevant condition is a necessary element of a set of conditions jointly sufficient for the harmful outcome.
Here, we used a clinically relevant condition, podocyte-driven kidney disease, as a model to show that inhibition of insulin signaling protects from renal disease, prevents kidney failure and enhances survival of animals with induced dysfunction of mitochondria.
Here, we used a clinically relevant condition, podocyte-driven kidney disease, as a model to show that inhibition of insulin signaling, achieved through cell type specific genetic deletion of insulin receptor alone or in combination with the IGF-1 receptor in podocytes, protects from renal disease, prevents kidney failure, and enhances survival of animals with induced dysfunction of mitochondria.
If it would not have occurred in the absence of the agency the agency will be a causally relevant condition or, if one endorses causal minimalism, a cause-in-fact of the harm.
They argue that in these cases the agency, though a causally relevant condition, did not cause the outcome.
The present study showed that intraperitoneal injection of OMVs derived from intestinal E. coli induced host responses which resemble a clinically relevant condition like SIRS that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, systemic induction of TNF-α and IL-6, and lethality.
Furthermore, OMVs induced host responses which resemble a clinically relevant condition like sepsis that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, and systemic induction of tumor necrosis factor-α and interleukin-6.
Sepsis is considered positive if two or more of the SIRS criteria are met (e.g., hypothermia, tachypnea, or leucopenia [1]); therefore, our observation clearly indicates that OMVs derived from intestinal E. coli induced host responses which resemble a clinically relevant condition like sepsis.
