Although insufficient to cause abnormal carpal posture or collapse on static radiographs, an isolated injury to the scapholunate interosseous ligament may be the harbinger of a relentless progression to abnormal joint mechanics, cartilage wear, and degenerative change.
Once clinically manifest, renal disease in MMA patients has a relentless progression to kidney failure as is illustrated by the linear decline of eGFR in the patient population, with a faster rate of decline apparent in those with more severe metabolic parameters.
In general, at the disease onset an estimated 85 90% of patients have a relapsing-remitting clinical course that is characterized by clearly defined relapses with full or partial recovery, whereas the remaining 10 15% have primary-progressive multiple sclerosis, which represents a relentless progression from the beginning with no remission (Compston and Coles, 2008).
After regression, there is a stabilization of skills, rather than a relentless progression, a feature that differentiates RTT from neurodegenerative conditions such as Batten disease or Huntington's disease.
Every day, countless terminally ill patients who have exhausted standard treatment options for their condition cling to the hope that an experimental, unproven therapy will provide a respite from the relentless progression of their disease, if not an outright cure.
Similarly, patients with type 1 diabetes may have a late onset and slow (but relentless) progression of disease despite having features of autoimmune disease.
Similarly, patients with type 1 may have a late onset and slow (but relentless) progression of disease despite having features of autoimmune disease.
The natural history of the condition is one of the relentless progression of weakness, with an estimated loss of strength between 3.5 and 5.5 % per year [ 17, 26].
There remains, however, a major need to slow down or reverse the relentless progression of the disease to prevent the evolution of disabling motor and nonmotor features that continue to cause disability despite the existing symptomatic approaches.
In the late chronic stages, remyelination failure is a prominent pathologic feature that probably contributes to the relentless progression of the disease.
And Greece must continue to meet the relentless progression of obligations to bondholders, civil servants and pensioners.
