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On the other hand, the EGFR-silenced cells had 2.3 % ALDH1-high cells, suggesting a relatively modest decrease.
Such a mechanism of accurate bypass would be consistent with results showing that Dpo4 can accurately bypass a number of N-alkylG substrates, with a relatively modest decrease in catalytic efficiency.
We consider that the wide range of mRNAs and, therefore, proteins, presumably targeted by miR-16 explains the large effects that a relatively modest decrease in its levels has on cell fate.
The lone exception is the spt16 -K579E mutant where we detected a stronger decrease in the occupancy of the mutant protein expressed from this allele than expected based on a relatively modest decrease in histone H3 occupancy.
Thus, in a dataset containing enough fragments to saturate the E. coli transcriptome, the lack of rRNA depletion greatly reduced the number of mRNA-derived fragments obtained but led to only a relatively modest decrease in the proportion of annotated E. coli ORFs detected.
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Consistent with this, we find that SPICi is quite robust to perturbations of confidence values in both the STRING human and yeast networks, with a steady but relatively modest decrease in average Jaccard, PR and semantic density values as increasing amounts of noise are added (Supplementary Table 3).
Thus, taking into consideration a wide range of studies in TgAPP mice and human genetics, relatively modest decreases in Aβ, of about 25%, are associated with cognitive benefits (Tables 2 and 3).
Yet the additions at position-3 that form the linker caused relatively modest decreases in binding affinity (Ki values: compound 2, 7 nM; compound 4, 15 nM).
Indeed, our findings suggest that for studies of differential gene expression, even significantly higher levels of multiplexing result in relatively modest decreases in sensitivity.
As shown in Figure 1B and 1C, background subtraction assuming 0.5% or 1% gDNA contamination led to relatively modest decreases in ORF and ncRNA coverage but to significant drops in coverage of IGR and AS positions.
And a relatively modest one at that.
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