Sentence examples for a relatively deleterious from inspiring English sources

Evidence from animal and human models indicates that dopamine DA impacts on PFC function in accordance with an inverted U-shaped dose-response curve, such that the response is optimized within a narrow range of DA activity, with too little or too much DA having a relatively deleterious effect [ 13, 14].

We assume, without loss of generality, that the selection coefficient s i > 0 so that a is the relatively deleterious allele at each locus.

However, we cannot rule out that other pathologic conditions associated with diabetes, such as hypertension, might have a relatively more deleterious effect on the brain than glucose levels.

Intracellular trafficking that diverges from cellular requirements is likely to exhibit relatively deleterious consequences leading to negative selection compared to cells that function appropriately.

One interpretation is that CNVs are relatively deleterious (compared with SNPs) and that natural selection often removes them from a population, following which little genetic variation in the form of CNVs may remain to characterize population differences.

This apparent loss of function at testis-expressed genes is consistent with a recent study (23), which showed that male-specific genes in humans carried a relatively high load of deleterious polymorphisms, possibly due to reduced selection on these variants in females who do not express these genes.

This indicates the presence of a relatively large number of slightly deleterious alleles in this gene, few or none of which became fixed in ancestral populations.

Recent work suggests that this sort of association is only likely to hold for deleterious alleles with a relatively small effect on phenotype (Thornton et al. 2013), which is consistent with the expected weak-to-intermediate effects of deleterious alleles likely to be involved in heterosis (Charlesworth and Charlesworth 1987; Whitlock et al. 2000; Glémin et al. 2003; Charlesworth and Willis 2009).

Plasma-sprayed ceramic coatings usually are characterized by a relatively high open porosity, which is deleterious when these coatings have to perform in an aggressive environment.

Remarkably, each stress condition was associated with a relatively distinct set of protective and deleterious factors, consistent with fundamental mechanistic differences in the cell death pathways.

The strong association between WHR and mortality in normal-weight women suggests that a relatively high degree of abdominal adiposity is deleterious despite being normal weight.