Sentence examples for a regulating target from inspiring English sources

SOX10 may also act as a regulating target and mediator of OLIG1 and OLIG2 during OPCs maturation [ 136].

To date protein posttranslational modification by ubiquitin or other ubiquitin-like molecules (i.e. SUMO, NEDD) has emerged as an important strategy for dynamically regulating target proteins involved in regulation of diverse cellular processes, including protein relocalization, stability and stress response [29] [31].

By directly or indirectly regulating target gene expression, miRNAs regulate a series of biological processes including cell cycle [ 16], growth [ 17], apoptosis [ 17], differentiation [ 18] and stress reaction [ 19].

Conversely, in sanroque mutant primary MEFs expressing a ROQUIN variant incapable of regulating target mRNAs, we found that stress granule recovery post-arsenite treatment was comparable to wild-type MEFs.

Rescued p53 behaves similarly to its wild-type counterpart in regulating target genes, reducing cell proliferation and increasing cell death.

NGF is normally available in only limited quantities in embryonic and adult tissues and, therefore, we hypothesize that as well as regulating target innervation density (Patel et al, 2000), it may also limit the number of neurons with an IA-current and may even be crucial to initiate mechanosensitivity in nociceptors.

Proposed central "hub" genes regulating target networks or other network regulatory mechanisms for ethanol behaviors can rapidly be validated in animal models through the use of viral vector gene targeting (Bhandari et al. 2012) or recent developments for rapid genetic targeting of specific genes (Gaj et al. 2013).

This suggests that regulators that are regulating targets whose desired expression levels correlate only moderately with the regulator's activity may be under selection for lowering their signal-to-noise ratios.

Aside from the 10 miRNA targets, MYC demonstrated another 291 protein-coding genes as its regulating targets.

For instance, they could achieve this by positively regulating targets within and outside the cell known to promote cell proliferation or negatively regulating targets within and outside the cell known to halt cell proliferation.

Among these common ones, MYC has the largest number of regulating targets (301) and the highest betweenness (46215.9).