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The second model considers disease as an endogenous entity and healing as a regulating activity that takes into account, rather than opposes, the symptoms of the disease.
The representation that people hold of flu may then place it in-between being an endogenous entity and an exogenous model [ 15], where healing is alternatively viewed as a regulating activity and the suppression of a hostile condition, according to the location of symptoms on the above-mentioned continuum.
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In turn, the ER itself may be activated in a ligand-independent manner by other signalling molecules such as growth factors and protein kinases that control the phosphorylation state of the ER complex and play a part in regulating activity of the ER (Katzenellenbogen et al, 2000).
FKRP may alternatively participate in an interaction with a Muscleblind partner potentially regulating activity or location in cell compartments, assist in protein dimerization [32], or others functions.
Recent studies show that phosphorylation of similar well conserved residues in the N-terminus of NKCC2 (S91, T95, T100, T105 and T118 in both human and ferret NKCC2 (fNKCC2)) plays a key role in regulating activity of this transporter too [10] [12].
This suggests that PPARγ supports syncytiotrophoblast differentiation by regulating activity of a nuclear/transcription factor(s).
In an effort to identify human genes involved in regulating activity of ERα, we constructed a high-throughput, cell-based functional screening platform by linking a response element (ERE) with a reporter gene.
However, an involvement of these photoreceptors in regulating activity or stability of GNA1 cannot be excluded.
In studying CREB's gene regulating activity in ethanol sensitivity, a set of differentially expressed genes in the ILS/ISS mouse model of ethanol sensitivity were examined.
This distance has been found to influence the strength of the splicing regulator [ 21], and there seems to be a distance beyond which a motif becomes inactive [ 22] or changes its regulating activity [ 23].
Cyclin E is involved in G1 to S phase progression by its regulatory association with CDK2 and also has a CDK-independent role in DNA replication by regulating activity of the replicative MCM helicase [ 34].
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