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The reformers' impulse to calm the unruly streets by creating a regulated play area is entirely understandable.
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These rules transform spontaneous play into games, which can thus be defined as rule-bound or regulated play.
Our observed high correlation (>0.7) between allelic expression in F1 hybrids and gene expression in parental lines indicates that a cis-regulated mechanism plays an essential role in allelic expression.
These tightly regulated mechanisms play an essential role in mammalian differentiation and phenotype development.
Although a gene does not have to be up- or down-regulated to play a key role in a biological process, screening for differentially expressed genes is one of the most straightforward approaches to reveal the molecular basis of a biological system.
A highly regulated protein always plays a critical role to receive, mediate or amplify signaling cascade, and a protein which intensively regulates others is usually characterized as an activator, inducer and transcription factor.
Other genes grouped in commonly up- or down-regulated clusters play a role in primary metabolism, energy regulation, cell rescue or interaction with environment.
Whilst we were unable to detect G72 expression in human fetal brain, it remains a possibility that G72 is developmentally regulated and plays a unique spatio-temporal role in human brain development, independent of an interaction with DAO.
This is the first report to show that RbAp46 as a Ras up-regulated gene plays a pivotal role in Ras-related lung metastasis through binding of the RbAp46 with HDAC1 and Sp1 to suppress RECK expression and activate MMP9.
We foresee that a key direction for future research is identifying which the NLRP3-regulated components play a critical role in mediating necrotic death, but not in other inflammasome activities.
These observations revealed a novel function for TG2 and suggested that TG2-regulated pathways play an important role in acquisition of drug resistance and metastasis by conferring the EMT-CSC phenotype in mammary epithelial cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com