"It's such a finely regulated organ that many of the technologies that have been available to study it have in one way or other disrupted the very thing we're trying to study".
The vasculature in the brain is an actively regulated organ which, on the one hand, is influenced by global changes of systemic parameters (systemic blood pressure, blood gases, and blood pH) and, on the other hand, is capable of locally directing the blood to the regions of demand with high spatial and temporal resolution.
Antler is a valuable model for the study of nerve growth and regeneration as the repetitive renewal of a highly innervated, developmentally regulated organ is not observed in other mammals.
These shared phenotypes suggested the involvement of each in a common signaling cascade that regulated organ size, which was subsequently demonstrated through additional genetic and protein interaction studies.
Our previous work revealed that ARGOS and OSR1 regulated organ growth by primarily affecting cell proliferation in a redundant manner [ 31].
Recently, its homolog in Arabidopsis, AGG3, was shown to be an atypical heterotrimeric GTP-binding protein (G-protein) γ-subunit that positively regulated organ size [ 31, 32].
Dr Satel seems to be the much better for the operation, by the way.Gary Becker at the University of Chicago has also written in support of regulated organ markets; you can see his exchange with Richard Posner on the subject back in January at their shared blog.
The prostate is an androgen-regulated organ and there is a long-standing interest in understanding the role of androgens in the development of PCa [ 2, 3].
The number of protein-coding genes cannot explain functioning of very finely regulated organs such as brain.
Immunoblot data showed high expression of both SAFB1 and SAFB2 in the immune system (spleen, thymus) and in hormonally regulated organs (uterus, ovary).
