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The short day-induced decrease in kisspeptin immunoreactive neurons in AVPV is partially a reflection of decrease circulating testosterone levels, but importantly decreases are also seen in castrate hamsters, demonstrating a direct photoperiodic effect (Greives et al., 2008).
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However, the Mecp2−/y-SC data (i.e., increased time spent in the open arms of the plus maze) could be alternatively interpreted as resulting from abnormal perception of the environment, as if the mutant mice are not completely able to perceive the danger of the unprotected walkway instead of a reflection of decreased anxiety.
This observation was probably a reflection of decreased chronotropic drive with terlipressin.
Is the apparent decrease in Paneth cell numbers in NEC an artifact of Paneth cell detection related to secretion/degranulation, or truly a reflection of decreased cell populations?
26 This however may be a reflection of decreased glucotoxicity and lipotoxicity associated with a longer duration of DPP-4 inhibitor therapy.
A slight decline was noted in case-patients 55 59 years of age, a reflection of decreased birth rates during World War II.
However, the diminished fluorescence was likely a reflection of decreased protein stability because the T62I mutant did not accumulate appreciable amounts of GFP protein.
In our previous studies, it was unclear whether decreased metastatic growth in response to COX-2 inhibition was a direct effect on metastases or simply a reflection of decreased primary tumour size (Connolly et al, 2002).
The older patients in our study experienced a significantly higher incidence of toxicities with the addition of bevacizumab compared to what has been noted in younger patients, which is likely a reflection of decreased organ function and increased vulnerability to infection in older patients.
To confirm that the change of vGAT staining intensity was not a direct result of patient's antibodies but rather a reflection of decreased neuronal excitation, coverslips were treated with KCl to depolarize neurons, increasing their activity, with or without patient CSF.
Research suggests the decline in AST may be more of a reflection of the decrease in independent mobility and this decrease may be associated with parental AST safety concerns [ 16, 17].
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