The phrase "a refined knowledge of" is correct and usable in written English.
It can be used when describing a deep, sophisticated understanding of a particular subject or field.
Example: "Her success in the industry is largely due to her refined knowledge of market trends and consumer behavior."
Alternatives: "an advanced understanding of" or "a deep comprehension of".
Therefore, a refined knowledge of the effects of these mutations may prove useful for understanding pathways that lead to, or mitigate, long-term health, prevention of cancer and late-stage disease.
For instance, to favour macrophage M2 phenotype or neutrophil apoptosis may help macrophages to dampen inflammation and would be an interesting therapeutic option but necessitate a refined knowledge of the roles of the different cell types in the successive phases of intestinal tissue response to radiation exposure.
Only a more refined knowledge of syringeal geometry will permit obtaining an understanding of syringeal biomechanics and mechanical loads experienced in vivo.
The recent AHRQ/NIH report shows that development of successful preventive strategies requires a more refined knowledge of risk and protective factors for dementia and AD as well as a validation of the observational studies with large intervention studies [ 7].
Unless you want to follow a career in the sciences, a refined knowledge in the sciences isn't completely necessary.
A more or less refined knowledge of Earth's varied terrain is necessary for many thematic applications of satellite imagery.
Genomics may contribute to personalised medicine by allowing refined knowledge of a diagnostic group or a subgroup characterised by its response to a treatment.
The refined knowledge of the mtDNA phylogeny to the level of complete genomes opened the doors to a wide spectrum of different applications of medical and forensic interest; see also [7], [8], [9], [10].
More refined knowledge of prognostic factors in young breast cancer patients will be of use in guiding therapy, including adjuvant chemotherapy, in these women.
This comparison will enable us to generate a refined framework of knowledge transfer which could be used as a basis for planning and evaluating knowledge transfer interventions.
The specific point we would like to stress in this paper reflects a more general gap – which is widely ignored – between the enormous quantity of information buried in the sequence data and the refined knowledge built up over several decades of studies on gene regulation and protein biochemistry (recorded in [ 23] to [ 27]).
