PO/W is a perfect reference coefficient in the cases when overall partitioning is targeted, e.g., for the description of pseudo-equilibrium disposition (section ).
The model partition coefficient was substituted by a reference partition coefficient using the Collander equation 1 in section.
If a reference partition coefficient is used instead of the model partition coefficient, the Collander exponent β must be used with each P term in eq 9, according to eq 1 in section.
We measured a reference diffusion coefficient in aqueous solution (1 cP) and also the diffusion coefficient in the nucleoplasm.
The friction coefficient µ is assumed to obey an RSF law (Dieterich, 1979; Ruina, 1983), as given by (3) (4) where a and b are friction coefficient parameters, dc is the characteristic slip distance associated with b, θ is a state variable for the plate interface, V is the slip velocity, and µ0 is a reference friction coefficient defined at a constant reference slip velocity of V0.
As a reference diffusion coefficient, we used 1.56 × 10−6 cm s−1.
Lipophilicity is usually parametrized by a reference partition coefficient (section ), which is defined as the ratio of activities (or concentrations, if they are sufficiently low) of the solute in a surrogate phase and the aqueous phase under equilibrium conditions.
As our calculations of protein diffusion built on a reference diffusion coefficient for green fluorescent protein measured in an intracellular environment [ 38], these factors can be considered to be taken into account at least partially, while impaired diffusivity of very large protein complexes that may violate the Stokes-Einstein relation were investigated separately (Fig. 6).
Using the cell cycle length of CDC28 as a reference, the coefficients are a = 0.70 and b = -1.58 for CDC15, and a = 1.37 and b = 5.71 for α-factor, meaning that the length of a cell cycle in CDC28 is 0.70-fold of the cell cycle length in CDC15 and 1.37-fold of that in α-factor, and the cell cycle in CDC28 starts 1.58 minutes earlier than in CDC15.
The pooled option uses the coefficients from a pooled model over both groups (including a group indicator) as the reference coefficients.
