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Treatment 1 determined a reduction of worm recovery with no sex bias.
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This outcome, expressed as % egg reduction, is an indirect estimate of a reduction of the worm burden (Cook 2003).
For example, silencing of the lea gene in C. elegans dauer juveniles caused a significant reduction of worm survival during induction of desiccation and in osmotic and heat stresses [ 56].
For the H. contortus populations, there was a reduction of 35% in the mean worm number in subgroup B1 compared to B2 (63 vs 97 worms).
Therefore we have initiated a large scale cluster randomized controlled trial (RCT) with the aim to assess the effect of anthelmintic treatment on insulin resistance, the hypothesis being that reduction of worm load to undetectable levels will lead to a higher degree of insulin resistance.
Reduction of worm and egg load was also found by many authors after treatment of S. mansoni-infected animals with medicinal plants extracts [ 10, 11, 13, 14].
Importantly, this chimeric protein provided greater protection in reduction of worm burdens and egg counts than did its individual component, Sj26GST.
However the reduction of worm burden induced by such vaccines can't consistently supply 40% protection in challenge experiments, a level that the WHO believes necessary for protection against schistosomiasis [ 5, 25].
Schistosomicidal activity of alkaloids has been proved by Miranda et al. [ 14] while reduction of worm motility and depression of egg output have been correlated to the presence of tannins in plants [ 31].
We show here that silica-NPs induce a reduction of progeny production in the nematode worm C. elegans.
In C. elegans it has been reported that worms with a reduction of function of an NPY-like receptor, NPR-1, phenocopy ethanol withdrawal [17].
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