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However, another mechanism may be suggested in our transcript profiling data, which illustrates a reduction in transcripts associated with terpenoid biosynthesis, which lies upstream of ergosterol production.
Quantitative expression analysis demon-strates a reduction in transcripts for both Sur and the inward rectifying potassium channel (Kir) subunits when IPCs are partially ablated.
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However, it is simple to determine if the late stage reduction in GFP translated from the GFP-312 mRNA is accompanied by a reduction in transcript levels.
Thus, according to the selection for energy cost hypothesis, highly expressed genes are likely to experience greater selective pressure for a reduction in transcript length [1].
The transcript denoted as R3 increased in abundance through growth in a manner similar to the observed expression profile of the sRNA MicA [25]; it increases monotonically, peaking in mid stationary phase prior to a reduction in transcript intensity through late stationary phase.
Two mechanisms may lead to cardiomyopathy inactivation of an allele (a null allele), leading to a reduction in transcript and functional protein (haploinsufficiency); or production of a mutant protein ("poison peptide") which interferes with normal function (dominant negative) or assumes a new function.
In both transgenic lines we observed a reduction in transcript accumulation of the genes evaluated, with the exception of AOX1A.
Overexpression of atwhy2 in Arabidopsis compromised mitochondrial function by causing a reduction in transcript levels and mtDNA content.
Thus, a large part of the mRNA response to hypoxia in A. fumigatus involves a reduction in transcript levels of genes associated with core cellular processes.
We observed an abrogation or a reduction in transcript levels of genes encoding CEAPs during the biotrophic phase and an abrupt induction in the necrotrophic phase.
A reduction in transcript levels in response to SSA could be also explained by reduced Pol II occupancy on these genes.
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