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HMMSplicer identifies more splice junctions than currently available algorithms when tested on publicly available A. thaliana, P. falciparum, and H. sapiens datasets without a reduction in specificity.
However, while unions of computational approaches may achieve a higher level of sensitivity than the individual approaches, this gain comes at the cost of a reduction in specificity.
While using more motifs increases the possibility of false positives (i.e. a reduction in specificity), since it becomes more likely for any sequence to contain an occurrence of any predictive motif by chance, the sensitivity of the predictor improves (data not shown).
Subsequently, an increase in the percentage of false-positive results has been observed, that is, a reduction in specificity.
The alternative thresholds identified for this high-risk population were only slightly more sensitive, with a reduction in specificity.
A reduction in specificity of the Mcm5 test, from 93 to 73%, was observed when using the expanded control cohort.
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The consequence of marker elevation in benign disease subjects with jaundice was a reduction in marker specificity for PDAC (specificities of markers ranged from 33%to7373%), compared with specificities for jaundiced PDAC patients over HCs (ranged from 76% to 100%) or over non-jaundiced benign disease subjects (ranged from 49%to9292%).
One of the proposed solutions to these challenges involves trading off a reduction in the specificity of informed consent protocols with an increased emphasis on governance.
The dedifferentiation theory of aging proposes that a reduction in the specificity of neural representations causes declines in complex cognition as people get older, and may reflect a reduction in dopaminergic signaling.
We find that the number of matches per read increases, suggesting a reduction in mapping specificity.
When the Indeterminate lesions were defined as benign there was an increase in sensitivity (from 55%to6767%) but there was a reduction in the specificity (100%-75%) and accuracy (75%-70%-70%th the addition of the 4D-PET/CT but again the results did not reach statistical significance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com