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Specifically there is evidence of variation across geographical regions and a reduction in efficacy over time.
A reduction in efficacy would become apparent when the affinity increases or vice versa if the affinity was reduced.
Specifically, induction of CYP metabolism could result in lower circulating drug concentrations, which could in turn lead to a reduction in efficacy.
However, their expense and complexity of use may result in low adherence with treatment in the long term, which may lead to a reduction in efficacy.
Results of a retrospective case review of 129 ustekinumab-treated patients with psoriasis have demonstrated a reduction in efficacy for individuals weighing 90 100 kg and also receiving 45 mg.
Because of the lack of a control group with no screening, we cannot determine whether this result was due to a reduction in efficacy of mammography screening in this age group or whether the effectiveness of triennial screening is similar to that of annual screening.
Similar(52)
However, our results suggest that any reduction in efficacy (if it occurs) does not have a dose response effect.
This results in a reduction in the efficacy of the transplant.
Doping with chromium and nitrogen generally led to a reduction in photocatalytic efficacy, however at the lowest nitrogen partial pressures, of 5 10% in oxygen, it is increased.
This error can relate to misleading results; specifically, inaccurate topic descriptions and a reduction in the efficacy of text mining classification results.
For example, paclitaxel i.e. 7-β-xylosyl-10 deacetyltaxol, a glycoconjugate of the taxane prodrug, has more than two orders of magnitude improved water solubility without a reduction in clinical efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com