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For LOH to occur, measured as a reduction in copy number, physical loss is required.
Haploinsufficient (HI) genes are those for which a reduction in copy number in a diploid from two to one results in significantly reduced fitness.
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Supplementation with NDSF resulted in an increase in 16S rDNA copies of Ruminococcus flavefaciens and a reduction in copies of Ruminococcus albus.
Our hypothesis posits that it is copy number variation (specifically, a reduction in gene copy number) of the orthologs of these genes that is relevant to human cancer.
A reduction in mtDNA copy number resulted in reduced levels of COX I in glomeruli at FSGS phase, suggesting that mt dysfunction by mtDNA depletion potentially plays a key role in the pathogenesis of FSGS in PAN.
Protozoa counts were not affected by treatment; however, a reduction in methanogen copy count number was observed when 3-nitrooxypropanol was fed (0.95 vs. 2.69 × 108/g of rumen digesta).
On the other hand, if there was Fpo monosomy, we might expect a reduction in gene copy numbers.
This implies that a reduction in IS copy number by spontaneous mutation alone is unlikely.
The haploproficiency phenotype is, by definition, linked to a reduction in gene copy number.
A reduction in the copy number of some of these genes in the results in growth rate above μmax in turbidostats (Additional File 3, Table S1).
In addition to structurally altering mtDNA, several disorders have been identified that are caused by a reduction in mtDNA copy number.
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