We concluded that InsR-A reduces sensitivity to gefitinib in LoVo CRC cells, thus its co-targeting alongside EGFR can improve the anti-tumour effect of gefitinib.
Our results suggest a reduced sensitivity for the emotional qualities of speech and music in alexithymia during affective categorization.
In sum, the results of this study suggest a reduced sensitivity to emotional qualities of speech and music in alexithymia at a neurophysiological level.
"The degree of cushioning that may be of use to a runner on a concrete footpath may be reducing sensitivity to feedback information from the foot (and potentially increasing injury risk) in individuals who play court and field sports that require rapid changes of angle and direction," Dr. Waddington said.
Simply correlating information from these different sensors is likely to decrease the rate of false alarms without reducing sensitivity to a clinically important degree.
Three main advantages of using ODs in an SD-OCT system are an ultrafast A-scan rate, reduced sensitivity roll-off, and linear- k spectral detection.
For example, a double log scale (logarithm of a logarithm) reduces sensitivity below classical single log scaling.
This was reflected in the observation that a restricted panel consisting of the four antigens p53, NY-ESO-1, Hsp70, and Prx VI exhibited only a slightly reduced sensitivity of 55%95%5% CI: 50 60%), but with an increased specificity of 98%95%5% CI: 93 99%) in the test cohort (Table 2 and 3).
Knockdown of a second member of the ppk family, ppk25, also resulted in a partially reduced sensitivity to CH503.
Considering chloroquine, monensin and bafilomycin A1, this tendency was confirmed with a significantly reduced sensitivity of LR-OPY1 CHIKV to these chemical (p<0.031 in any case).
