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"She is on a reducing dose of medication.
The largest trial of steroids in TBM used a reducing dose of dexamethasone, initially given intravenously at a dose of 0.3 to 0.4 mg/kg/day (depending on the severity of the meningitis) for a total of 6 to 8 weeks [ 65]; British guidelines suggest prednisolone (or equivalent) 20to4040 mg/day with gradual withdrawal.
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In patients with moderate CKD (CrCl of 30 50 mL/min) 34 a reduced dose of edoxaban 30 mg daily is recommended.
In this patient, fatal CMV enterocolitis developed when he was placed on a gradual reducing dose of prednisone, from 40 to 30 mg.
One patient in the capecitabine group was identified with a heterozygous DPYD*2A mutation and was treated with a 50% reduced dose of capecitabine.
If the ANC was ⩾1000 μl−1 but <1500 μl−1 and the platelet count was ⩾75 000 μl−1 but <100 000 μl−1 on the scheduled day 1 of the next cycle after a 1-week delay, treatment could be started with a 25% reduced dose of capecitabine or at the next lowest dose level for S-1.
This results in a significantly reduced dose of recombinant FSH/hMG while the outcome is comparable to traditional COH regimens (Filicori et al., 2005a, b).
Furthermore, Saugel et al. showed that argatroban should be initiated at a markedly reduced dose of about one tenth to one eighth of the recommended dose in ICU patients with multiple organ dysfunction syndrome [ 16].
To avoid excessive anticoagulation and bleeding complications, argatroban should be initiated at a markedly reduced dose of about one tenth to one eighth of the recommended 2 μg/kg/min in ICU patients with MODS.
A recent report made the observation that individuals with a Met/Met genotype (associated with significantly decreased COMT activity) at the Val158Met polymorphism of the human COMT gene required a significantly reduced dose of morphine to achieve pain relief, as compared to individuals with the Val/Val genotype [ 10].
A single patient with DAD discovered on chest CT in the non-UIP IIPs group died of respiratory failure 2 weeks after the initiation of steroid pulse therapy, and another patient with HP discovered on chest CT in the UIP group was administered 500 mg/day methylprednisolone for 3 days with a gradually reduced dose of oral prednisolone after steroid pulse therapy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com