Both the issue of using the Danish National Patient Register as gold standard and the reduced validity of a few of the indicators stress the importance of careful consideration and evaluation of the completeness and validity of the different components of registers.
Behavioral tests such as the delay of gratification and the delay discounting test gain a greater importance in this sample because of the reduced validity of the self- and informant-reports.
To cope with the reduced validity of the scientific inference due to misrepresentation we used Multiple Imputation by Chained Equations.
In some studies, slight possible benefits in relapse outcomes were found with omega-6 fatty acids, but data were characterized by the reduced validity of the endpoints.
In order to balance the importance of long-term cost-effectiveness with the potentially reduced validity of literature-supplemented cost estimates, results will be reported primarily in terms of measured cost-effectiveness to 18 months, and secondarily in terms of modeled cost-effectiveness through the lifetime.
Firstly, the reduced number of successful blood collections may be considered as a limitation and could reduce validity of presented results.
Validity of the Pedar system was highest (RMSE 2.6 kPa; difference 3.9%), with the Medilogic (RMSE 27.0 kPa; difference 13.4%) and Tekscan (RMSE 27.0 kPa; difference 5.9%) systems displaying reduced validity.
A number of criticisms of this position have been put forward, based on issues such as the difficulty of designing a placebo-like control, the impossibility of maintaining double-blind conditions, the challenge of standardizing interventions, the importance of the therapist-patient fit, and the reduced external validity of psychotherapy in the context of a RCT [ 3].
Nevertheless, there is extensive research evidence from the NHS acute hospital sector that poor patient recruitment or retention of patients to clinical research is widespread, leading to delays in the start or completion of both academic and commercially funded research, the reduced external validity of studies, and wasted public resources and opportunity for patient participation [ 3– 6].
These results support the validity of a reduced version of the H-PEPSS and suggest it can be appropriately used at or near training completion with a variety of health professional groups.
