Sentence examples for a reduced propensity for from inspiring English sources

Therefore, agonist-specific differences in DOR regulation suggest that by further chemical modification, δ-selective opioid analgesics can be designed that exhibit a reduced propensity for analgesic tolerance.

In addition, methotrexate is independently associated with a reduced propensity for metabolic syndrome, thus suggesting a drug-specific mechanism [ 39].

The same result can be obtained if there is a reduced propensity for a recombinational interaction to be specified to be a crossover.

The LGICs thus present attractive targets for new therapeutic agents with improved discrimination between receptor isoforms and a reduced propensity for off-target effects.

These survival mechanisms include a reduced propensity for certain tumour cells to die under conditions of stress and may be driven by genetic aberrations such as loss of p53 function [ 164, 165].

These survival mechanisms include a reduced propensity for tumour cells to die under conditions of stress and may be driven by genetic aberrations such as the loss of p53 function (Yu et al, 2001, 2002).

37 This might imply that insulin detemir has a relatively reduced propensity for stimulating lipid storage in adipocytes, and implies a more physiologic gradient of action between the liver and periphery.

One of these Pol III variants was selected for further study and shown to have a faster elongation rate and reduced propensity for pausing in vitro (Shaaban et al. 1996), consistent with expectations if the mutation caused a decreased association with Rpc37/53.

This study provides evidence of a link between primary care supply and reduced propensity for cesarean section.

Targeted covalent inhibitors exhibit slow target offset, increased binding efficiency and potency, enhanced selectivity, reduced propensity for target-based drug resistance and prolonged pharmacodynamic effects.

Increased clonogenic survival is observed in CD24-/low/CD44+ CD24-/low/CD44+om mammosphere culTICss anderivedsociated with (a) reduced production ofromactive oxygen species, (b) attenuated activation of γH2AX and CHK2-p53 DNA damammosphereing pathways, (culturesed propensity for ionizing randatisn-induced associated and (d) altered DNA double-strand or DNA single-strand break repair.