Sentence examples for a reduced propensity from inspiring English sources

Ligands that promote endocytosis of the MOR have a reduced propensity to cause antinociceptive tolerance compared to morphine which does not [41] [43] and see Figure S1A).

Sequence analysis of NEDD1 suggests that residues 635 642 have a reduced propensity to form a helix (Figure 2B) and analysis of the CD data at 222 nm predicts that the purified CTD protein is only 70% helical (222 value of -35 000 degrees cm2 dmol−1 was taken to correspond to 100% helix, see methods).

In addition, the lesser extent of PCD features even at high CQ concentrations suggests that these CQ-resistant strains may have a reduced propensity to undergo PCD.

This work suggests a strategy to develop novel analgesics that have a reduced propensity to cause tolerance, physical dependence and addiction.

Initially, it was reported that relatively selective COX-2 inhibitors such as nimesulide and meloxicam had a reduced propensity to cross-react with aspirin in patients with AERD, particularly at low doses [ 3].

As for pure S-cones, our small recorded sample is in no way sufficient to conclude that they have a reduced propensity to couple to rods, since we found uncoupled cones also within the S/M group.

For example, cells with a gain of chromosome 20q11.1-11.2 had a significantly reduced propensity to differentiate down the hematopoietic lineage and in the neural differentiation experiments the variant cells displayed more immature phenotypes along the differentiation trajectory than their wild-type controls (Werbowetski-Ogilvie et al., 2009).

37 This might imply that insulin detemir has a relatively reduced propensity for stimulating lipid storage in adipocytes, and implies a more physiologic gradient of action between the liver and periphery.

Apart from a strongly reduced propensity to bind microtubules, non-phosphorylated wild-type Eg5 as well as a non-phosphorylatable Cdk1 mutant of Eg5 are mechanochemically functional as judged by their microtubule gliding activity in vitro.

Selective COX-II inhibitors such as rofecoxib, celecoxib, and parecoxib have shown consistently comparable efficacy to that of conventional NSAIDs in patients with rheumatoid arthritis, with a significantly reduced propensity to cause gastrointestinal toxicity.

One of these Pol III variants was selected for further study and shown to have a faster elongation rate and reduced propensity for pausing in vitro (Shaaban et al. 1996), consistent with expectations if the mutation caused a decreased association with Rpc37/53.