Peptide-tolerised T helper cells proliferated to a much reduced extent in peptide-free IFA-only treated second recipients after virus infection (Figure 1H), indicating a partially reversible intrinsic non-responsiveness of the transferred GP61-specific T cells.
The consequence for the pathogenesis was a significant reduction in latency amplification, reflected by a reduced extent of splenomegaly, a lower number of reactivating splenocytes and a reduced genomic load during the amplification phase.
An element of the procedural discussions in TLE surgery is whether a reduced extent of resection is associated with a lower rate of seizure freedom and vice versa.
A reduced extent of herpetic rash was the only factor to correlate with a good outcome of PHN.
Immunisation of the mice with recombinant pGP3 or pGP4 protein caused a significantly lower chlamydial burden in the lungs of the infected mice; the lower IFN-γ level indicated a reduced extent of inflammation.
On the other hand, the Drosophila ortholog eag is also known to induce an increase in cell proliferation independently of ion influx [13], and a non-conducting KV10.1 point mutant still promotes tumor progression, although to a reduced extent [11].
As shown in Figure 1, over-expression of AtTCTP clearly suppressed the pro-apoptotic effect of BAX indicated by reduced ion leakage levels, a reduced extent of chlorosis, and a diminished amount of dead cells.
We will use here HA derivatives with a reduced extent of sulfation.
Similar activations in frontoparietal regions were seen in each group individually, although with reduced extent in the ADHD group.
Similarly, conjunction analyses indicated ADHD patients appeared to engage broadly the same brain regions as controls whilst performing the task and in particular frontoparietal areas, albeit with reduced extent, a finding common in patient groups.
