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After surgery, trans people will continue to take hormones for the rest of their lives, but probably at a reduced dosage.
When it became clear that the shortage of agalsidase-β would not be resolved quickly, some patients who were already receiving agalsidase-β were treated with a reduced dosage so as to preserve the supplies of agalsidase-β.
To take full advantage of its unique properties, remifentanil must be started on its own and titrated to response before the addition of a sedative agent at a reduced dosage.
> -wrap-foot> FHH3 is associated with heterozygous loss-of-function AP2σ2 mutations, and these could be causing the disease by either haploinsufficiency (i.e. a reduced dosage of the wild-type AP2σ2 protein) or dominant-negative effects on the heterotetrameric AP2 complex.
(A) Electropherogram showing a reduced dosage of exons 9 13 (arrows) in patient RP40.
Due to the side effects of steroids, a reduced dosage was necessary, resulting in a deterioration of pulmonary functions and radiological findings concurrent with positive immunological markers.
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Treatment was interrupted when a patient had a non-haematologic toxicity of >grade 2 during treatment, and restarted at a 25% reduced dosage after the toxicity had resolved to a level of <grade 2. If a patient had severe toxicity at the time of a scheduled retreatment, drug administration was postponed until the toxicity had resolved.
CSCs are defined by their stem cell like self-renewal capabilities, their ability to differentiate into cell types that constitute the bulk of the tumor, and to initiate tumors at a significantly reduced dosage in mouse xenograft studies [7], [14].
All patients went through bilateral STN-DBS electrode implantation (Medtronics, USA) and were under dopamine replacement therapy (DRT) both pre- and post- DBS, with a significantly reduced dosage post-DBS (t-test p < 0.01).
It enabled the provision of velaglucerase alfa, an investigational drug at the time, to patients with GD1 who were faced with an interruption, delay, or reduced dosage of imiglucerase.
Reduced dosage in such a trans-acting repressor gene would consequently lead to increased expression of the target gene.
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