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Our subsequent functional analyses demonstrate that mature osteoclasts, whose platelet-derived growth factor bb (PDGF-bb) expression is reduced by siRNAs, exhibit a reduced capability of attracting osteoblasts.
Degraded successive-stimulus masking inhibitory mechanisms were associated with a reduced capability of neurons to follow higher-rate repetitive stimuli.
Finally, computational, biochemical and cellular studies indicated that the reduced nuclear shuttling of ERK1 causes a strong reduction of its nuclear phosphorylation compared to ERK2, leading to a reduced capability of ERK1 to carry proliferative signals to the nucleus.
Moreover, our study highlights the possibility that homeobox transcription factors may mitigate inflammation, or that a low expression during obesity may predispose to inflammation because of a reduced capability of tissue repair.
In sum, these cells harbored mispaired TCR dimers and a reduced capability of prober P14 TCR pairing.
Diabetes mellitus (DM) is a major risk factor for micro- and macrovascular complications[ 1, 2] and is associated with endothelial dysfunction, premature atherosclerosis [ 3- 5], and a reduced capability of neovascularization in ischemic conditions[ 6].
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In agreement with the different transcription profiles of this gene during sclerotial degradation of the two plant pathogenic fungi B. cinerea and S. sclerotiorum, we found a reduced capability to parasitize the sclerotia of B. cinerea but not of S. sclerotiorum.
However, in NP cells derived from degenerate discs, a reduced capability to divide was seen with cells capable of only 20 to 25 population doublings prior to senescence.
Description: Longitudinal or lateral cracks of concrete sleepers lead to a reduced capability to deal with torque, which might lead to an increased width of the track gauge.
A reduced capability to increase intestinal calcium absorption and/or renal conservation of minerals during pregnancy and lactation might lead to a greater skeletal response and, hence, to greater mobilization of calcium from bone.
These results suggest that the cell wall of ral1 mutant root tips had a reduced capability to bind Al, resulting in increased resistance to Al.
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