Although transient or recurrent increases in alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) above the upper limit of normal (ULN; 55 U/l) were common as patients were also receiving methotrexate, no patients developed evidence of methotrexate hepatotoxicity.
The eye that tested positive for HSV (Figure 1) had a history of recurrent inflammation, increase in IOP, pigmented KPs, and irregular iris stromal atrophic areas.
In this trial, vena cava interruption using a definitive vena cava filter was associated with an early reduction in the risk of recurrent PE but with a late increase in recurrent deep vein thrombosis without significant difference in the risk of recurrent venous thromboembolism or death [29, 31].
However, patients with Child-Pugh B, ECOG 1, bilobar disease, and recurrent disease showed a significant increase in objective response (P = 0.038) compared to cTACE.
Rivaroxaban was superior to placebo for the prevention of recurrent VTE, without a significant increase in major bleeding (Table 3) [ 57].
A separate budget was established for mental health and there was an increase in recurrent mental health spending [ 28].
The sector wide analysis has shown an increase in recurrent expenditure largely accounted for by increase in the wage component while the non wage recurrent remained fairly constant.
Candidate gene studies have demonstrated that rare (minor allele frequency, MAF < 1%) loss-of-function variants in DNA repair genes, in particular BRCA2, as well as a recurrent missense variant in HOXB13 confer moderately increased disease risks; however, these explain only a limited fraction of the overall heritability (2, 3).
It is also associated with poor growth, and an increase in recurrent minor infections [ 25].
Chronic exertional compartment syndrome (CECS) is classically defined as a condition presenting with recurrent, ephemeral increases in pressures of confined muscle compartments during exercise.
