We use a set of known HIV receptors, their functional annotations and human protein interaction data as a scaffold for building an HIV receptor network.
We build an HIV receptor network from the remaining receptors and rank the proteins according to their centrality within the network.
Finally, we consider all 13 known HIV receptors as seeds to build an
We generate a specific HIV receptor network using known receptors as seeds (see Table 1).
Taken together, the classical view that IGFs bind and activate IGF1R and INS activates INSR greatly simplifies the biological situation in which IGF/INS-responsive receptors constitute a complex interacting receptor network.
To study this, we build an enriched HIV receptor network from known HIV receptors and rank all its proteins according to their centrality within the network.
Therefore, an enriched HIV receptor network is built from documented surface membrane factors by populating it with functionally related proteins that either interact directly with or show significant functional similarity to any known factor.
To answer these questions by addressing the death receptor network on a quantitative level, the emerging field of systems biology was implemented.
Importantly, a number of new ways to regulate the death receptor network were made.
The causal relationship of EGFR and HER2 receptor network to disease progression and resistance to therapy provides a rationale for therapeutic intervention.
