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According to a recent study, discovery and development costs, a key indicator for the industry, tripled from 1999 to 2006, to nearly $15 a barrel.
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In a recent study, a false discovery rate of 87% was reported.
A recent study described the discovery of low density granulocytes (LDGs) whose greater tendency to undergo NETosis elicited a stronger immune response than conventional neutrophils [ 57].
A recent study successfully led to the discovery of new activities and pathways through the exploration of the enzymatic diversity of a protein family of unknown function [ 52].
A recent study published in Cell Death Discovery, demonstrates that ALS-associated mutant FUS also dysregulates the early stages of autophagy, by inhibiting the formation of the autophagosome, an early stage in the process.
In a recent study published in Cell Death Discovery by Boyko et al., the minimal polypeptide of ING1b required to efficiently induce apoptosis was defined using a series of deletion mutations followed by different tests to determine their ability to induce cell death.
In a recent study published in Cell Death Discovery, we not only demonstrate a role for pro-apoptotic Bcl-2 homology domain-3-only protein Bmf (Bcl-2-modifying factor) as a mediator of beta-cell apoptosis in a mouse model of a monogenic form of diabetes, HNF1 α-MODY, but also reveal an extracurricular role for Bmf in beta-cell insulin secretion unrelated to cell death initiation in vivo.
In a recent study, Carrano and colleagues report the discovery that an E2/E3 ubiquitin ligase set are required for the lifespan extending effects of DR in C. elegans [ 1].
For example, a recent study reported on the genome-wide discovery of induced single base substitutions and the prominence of single base deletions in six FN-irradiated Arabidopsis mutants (Belfield et al. 2012).
Although estimates of drug discovery costs vary (a recent study suggested that the minimum cost of developing an NCE is US$204 million [ 6]), it is important to note that these estimates do not yet account for drug failures.
Our discovery was confirmed by a recent study in zebrafish showing that a small molecule that inhibits PDE4 promotes Hh signal transduction (Williams et al., 2015).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com