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A recent functional study provided evidence for an alteration of the function of the ATP-sensitive potassium channel in the β-cell, encoded by KCNJ11 and ABCC8, when these two variants were coexpressed [ 77], possibly explaining previous inconclusive reports of investigations of a single mutation.
In a recent functional magnetic resonance imaging (fMRI) study in young adults, we found greater specificity of phoneme representations, as measured by multivoxel pattern analysis (MVPA), in left PMv and Broca's area than in bilateral auditory cortices during syllable identification with high background noise14.
Moreover, a recent functional study demonstrated that in mouse models of tuberous sclerosis and fragile X, two different forms of syndromic autism, the autistic phenotype was ameliorated by modulation of GRM5 in opposite directions for each syndrome, which suggests that GRM5 functional activity is central in defining the axis of synaptopathophysiology in syndromic autism55.
A recent functional magnetic resonance imaging study suggested that this association may be mediated by 5-HTTLPR effects on the response bias of the human amygdala-a brain region critical for emotional and social behavior-to environmental threat.
In addition, a recent functional study demonstrated that a Pro446Leu mutation in rs1260326 resulted in attenuated fructose-6-phosphate enhancement of GKRP activity in the liver [40].
A recent functional neuroimaging study of the GABAergic system has revealed negative BOLD signal changes in the pregenual ACC in humans [53].
In a recent functional MRI study, PWS individuals had higher activities of blood oxygen dependent response to pictures of food than to pictures of animals or tools.
A recent functional imaging study has shown robust activation of the thalamic areas including the habenula when normal subjects make errors in the behavioral flexibility test; in contrast, such activation is absent in schizophrenia patients [15].
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A recent functional-genomics study characterized Nerolidol Synthase 1, the enzyme that catalyzes the formation of the flavor compounds linalool and nerolidol from geranyl diphosphase and farnesyl diphosphate, respectively.
Although the evidence from lesion studies strongly implicate the left posterior temporal cortex in language processes, a recent functional-anatomical model has proposed that the acoustic analysis of heard speech and lexical access is a function of both the left and right posterior temporal cortex (albeit with a 'weak left hemisphere bias') (Hickok and Poeppel, 2007).
However, SMD and BP differ in the brain mechanisms underlying these emotion labelling deficits a recent functional magnetic resonance imaging (fMRI) study showed that patients with SMD had lower amygdala activity compared to those with BP during a face emotion processing task [ 15].
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CEO of Professional Science Editing for Scientists @ prosciediting.com