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The huge number of calls needed to get a reasonably sized sample also drives up the cost.
Because such variants are rare, either they must have strong effect sizes or there must be multiple causal variants clustered within a gene to have power to detect the association with a reasonably sized sample.
Today, getting that same number of respondents requires between 7,500 and 9,000 calls to get a reasonably sized sample, a precipitous decline in what's called the response rate, which is seen as a crisis in the industry.
Moreover, for a reasonably sized sample, there will be an almost infinite number of possible partitions of the same data.
There is clearly a call for a direct comparison between multidimensional QOL of a reasonably sized sample of female MI survivors and that of the general female population of the same age range, as well as a thorough evaluation of the clinical importance of the resulting findings.
While any single analysis will not be very insightful from a general point of view, there are two big questions one would like to ask of a reasonably sized sample of such analyses: First, how different are the DMEs for different systems?
Similar(53)
While the results of each study give cause to believe that genome association approaches can deliver novel genes, the costs are likely to prevent similar approaches being applied in all reasonably sized samples across the whole spectrum of complex disorders.
Recent advances in GWAS using mixed models represent a breakthrough compared to older methods, and allow analyses of a limited number of traits in reasonably sized samples even on personal computers.
In the language of statistics, the vast majority of reasonably sized samples are representative of their population, that is, closely resemble it in complexion.
The behaviour of the DFC test ROC and SPA curves displayed in Figures 4 and 5 agrees with what one would expect from a test performing better than the standard t-test on a reasonably sized (more than 10 samples) data set with ~ 100 differentially expressed features.
Moreover, our memory was too small to create a reasonably sized buffer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com