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Most rational surrogates are unwilling to continue life support after a reasonable trial has demonstrated that its benefit has passed the point of diminishing returns.
While medications that are strictly for anxiety often do produce benefits within anywhere from a few minutes to an hour, antidepressants that are used to treat both depression and anxiety may take longer to make a difference, with 2 weeks being a reasonable trial period.
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Everybody has to agree what is a reasonable clinical trial design.
The cost in experiments has been decreased through reasonable trial design.
That burden of proof is not very demanding and requires a showing far less demanding than the "beyond a reasonable doubt" test used in criminal trials ordinarily.
In this way, it is possible to compare the subjective quality distortions of different types with a reasonable number of trials.
As opposed to this, clustering large molecules with structured internal motion, such as B4402 and B4403, yields well-defined minima after a reasonable number of trials.
Far from there being enough evidence beyond a reasonable doubt, even the trial judge said later that he would not have voted to convict.
The relationship of each adverse event to the trial medication will be determined by a medically qualified clinician according to the following definitions The adverse event follows a reasonable temporal sequence from trial medication administration.
40 In light of these neutral results, it prompts the question "Do we expect too much from this predominantly frail population, with a high incidence of cognitive impairment, depression, and dementia, to respond to individual activity based interactive interventions (fig 2)?" A reasonable conclusion from this trial is that most participants were incapable of engaging in therapy.
Instead of proof beyond a reasonable doubt, as criminal trials demand, the measure is a "preponderance" of evidence, as in civil trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com