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Serum ALT, a hepatocellular enzyme, is a reasonable marker of fat accumulation in the liver in nonalcoholic fatty liver disease (23).
Still, NO2 has been shown to be a marker of air pollution from road traffic [ 42] and could be a reasonable marker of ultrafine particulates or PAH from this source.
It is worth recognizing, however, that FFAs are implicated in the development of β-cell dysfunction, and FFAs are released from adipocytes, which make them a reasonable marker of lipolysis (9, 10, 27, 30).
We excluded 784 births (0.2%) where there were no data available about birthweight and 15030 births (4.1%) in which either parent was age 18 or younger because we were concerned that educational level could not serve as a reasonable marker of SES for parents who were not old enough to have graduated from high school.
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Foxp3 is considered a reasonable marker for the presence of Tregs in tissue.
Therefore, this complication seems to be a reasonable marker for the overall condition of the patient, given their injuries, and thus is an appropriate intermediate outcome measure [ 18, 19, 22].
However, even in the absence of this correction, serum VEGF appears to be a reasonable indirect marker of overall tissue VEGF levels (Poon et al, 2003).
We excluded a small number of markers from the analysis for these reasons, if they were located in regions of reasonable marker density (i.e. ∼8 10 cM between markers).
For example, two of 14 point estimates of Nb (and 5 of 14 upper-bound CIs) based on ldne could not be distinguished from infinitely large values, despite relatively large sample sizes (minimum sample sizes of 120 individuals per larval cohort) and a reasonable number of marker loci (15 microsatellite loci).
By choosing an empirical r limit of 0.2, we arrived at an LD covering approximately 5 cM for subgroup Gsub1 and 20 cM for subgroup Gsub2; these values suggest that it would be possible to cover the entire genome with a reasonable number of markers, i.e., approximately 290 and 70 markers, respectively.
We chose KASPar technology as it seems to be the most appropriate technology for the most frequently encountered mapping situations in crop genetics – (a) relatively small populations and a reasonable number of markers for genome-wide linkage mapping and (b) large populations and a small number of markers for specific-region fine mapping.
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