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Foxp3 is considered a reasonable marker for the presence of Tregs in tissue.
In the Fresno/Clovis study area, the main source for NO2 is traffic; therefore, NO2 is a reasonable marker for traffic-related pollution (Watson et al. 2000).
Serum ALT, a hepatocellular enzyme, is a reasonable marker of fat accumulation in the liver in nonalcoholic fatty liver disease (23).
Although potassium is a crustal element, it is generally considered a reasonable marker for vegetative burning, including residential wood combustion (Maykut et al. 2003; Watson et al. 2001).
EC, the tracer for diesel particulates used by Sarnat et al. (2008), is likely a reasonable marker for diesel exhaust in this study as well.
Potassium (K) is generally considered a reasonable marker for biomass combustion, including residential wood burning (Maykut et al. 2003; Watson et al. 2001), which is an important contributor to air pollution in Seattle.
Similar(48)
Genome-wide association studies overcome these restrictions, given reasonable marker saturation and an appropriately diverse population.
However, even in the absence of this correction, serum VEGF appears to be a reasonable indirect marker of overall tissue VEGF levels (Poon et al, 2003).
As an index of endothelial function, FMD can be viewed as a "barometer" of vascular health and is considered a reasonable surrogate marker for assessing atherosclerosis (Perticone et al. 2001; Sorensen et al. 1997).
These data established that evaluating the peripheral blood mononuclear cells is a reasonable surrogate marker for proteasome inhibition in tumors, at least for multiple myeloma involving the bone marrow.
We excluded a small number of markers from the analysis for these reasons, if they were located in regions of reasonable marker density (i.e. ∼8 10 cM between markers).
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