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The determination of an appropriate sample size for an experiment is important and should be in accordance with a reasonable effect size.
However, larger group sizes in the crossover analysis (chocolate groups n = 26, capsule groups n = 36) assessing acceptability of the two treatment forms led to a reasonable effect size > 0.9.
Given the relatively short assessment period, the size of the study population, and the resulting power to detect a reasonable effect size, it is not feasible for our evaluation design to use population-based indicators, such as maternal mortality ratios and neonatal mortality rates, as outcome measures.
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Indeed, such sample sizes may be required to validate and properly model biomarkers of reasonable effect size.
23 We collected data on 2,132 children with diarrhea in the 2 weeks preceding the survey, which granted adequate power to detect a range of reasonable effect sizes in the logistic regression analyses of care-seeking and treatment.
It is reasonable to assume a large effect size in this population based upon previous research [ 37, 38] and their memory performance on the digit span.
The design of our study differs from previous studies and it is not possible to make any firm inference for our study, although it is reasonable to expect a similar effect size.
All three approaches are part of our "5-steps to quit" intervention and it is reasonable to expect an effect size of at least 94% in our study.
Using a reasonable population estimate of 11% for a primary composite endpoint of perinatal death or morbidity for women randomised to the ursodeoxycholic acid comparison, a trial with reasonable power to detect a plausible effect size can be designed.
When planning a trial, one essential step is the calculation of a sample size, which will allow a reasonable chance (power) of detecting a pre-specified difference (effect size) at a given level of statistical significance.
We therefore believe this is a reasonable estimate of the plausible effect size in the suggested trial, and that documentation of a 0.5 between-groups effect size in this trial would provide reasonable support for clinical benefit in this population.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com