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As long as the best template can be identified, we can generate a reasonable alignment as shown in Figure 1.
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Despite the relatively modest level of sequence identity, a reasonable alignment could be made.
However we could not construct a reasonable alignment to conduct phylogenetic analyses, because sequence similarity was evident only in a limited region.
In the studying process, we found that the best alignment based on the lowest RMS sometimes was not the most appropriate for a subsequent CoMFA analysis, and artificial adjustment was usually needed to get the reasonable alignment, as shown in Figure 3.
Regarding the correlation of radiographic and navigation measurement in limb alignment Stulberg and coworkers [ 18] recently reported a reasonable discrepancy as much as 8° in reading out the results.
That's a reasonable argument, as far as it goes.
Unfinished (incompletely sequenced) clones are noted only where there was no reasonable alignment with a finished clone.
"We periodically assess the impact of local pricing of our products and services to ensure there is reasonable alignment across the region and this change is an outcome of this assessment," Microsoft said.
The state " skip" is an extra state for each exon alignment stage for the cases that there is no reasonable alignment available for one certain exon.
This is interesting in utterance copy because the other four metrics require a reasonable time-alignment between the target and synthetic signals while P.563 does not.
These scoring functions should be defined in such a way that biologically reasonable alignments or trees are more likely to receiving higher scores than biologically meaningless ones.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com