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The phrase "a really unfortunate combination" is correct and usable in written English.
It can be used to describe a situation where two or more elements come together in a way that leads to negative or undesirable outcomes.
Example: "The lack of communication and tight deadlines created a really unfortunate combination that affected the project's success."
Alternatives: "a truly regrettable mix" or "an unfortunate pairing".
Exact(1)
"It was just a really unfortunate combination of circumstances".
Similar(59)
"That strikes me as a really unfortunate precedent to set".
"That was a really unfortunate situation," Ms. Besteman said.
He added: "It's just a really unfortunate incident.
"It's a really unfortunate situation, and I am open to all suggestions".
"Sorry, I have a really unfortunate knack of being honest," she grins.
"It's a really unfortunate situation," Tanzella said.
"It's just a really unfortunate situation, I don't think anyone's to blame".
"I feel like we started [the business] at a really unfortunate time," Su says.
"I think that what's hard is that she's the victim of something that was really scary and a really unfortunate incident," Stevens said.
But more importantly, this would be a really unfortunate thing to watch.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com