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The test material has to be a realistic sample of the actual data that belongs to the target application scenario.
Unfortunately, many datasets are not made publicly available; and those that are frequently used do not contain a realistic sample of degradation types targeting a specific application under study, or their limited size does not allow for statistically significant results.
The synthesis tool, implemented in AIMMS®, is applied to a realistic sample problem, showing profit optimisation by varying the distribution of NG to syngas generation units with different efficiencies.
This effect size was chosen because it yielded a realistic sample size.
First, CASP targets comprise a realistic sample of currently solved protein structures and exemplify the corresponding challenges for predictors.
This also means that the calculation of Bayes factor before a realistic sample size has been reached will also be relatively unreliable, because the observed effect size used to calculate Bayes factor might be erroneous (Additional file 1: Table S1).
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A realistic sampling protocol also needs to be defined, with no redundancy.
The adaptive trial design is complex and is probably less efficient compared to the sequential design including a predefined realistic sample size [ 29].
This improvement in the conformer acidity predictions for both ensembles reflects the benefit of a physically realistic sampling of the protein conformational distribution.
We see this as positive because discussion would likely lead to more realistic sample size calculations – an outcome that would be of great benefit for the field of complementary and alternative medicine.
Evidence-based effect size estimation helps justify assumptions in light of empirical evidence and can lead to more realistic sample size calculations, an outcome that would be of great benefit for the field of complementary and alternative medicine.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com