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The phrase "a real difficulty to" is correct and usable in written English.
It can be used when discussing a specific challenge or obstacle that someone is facing.
Example: "Finding a reliable source of funding has become a real difficulty to our project’s success."
Alternatives: "a significant challenge to" or "a major obstacle to".
Exact(1)
"But there is in the region a real difficulty to identify the way forward".
Similar(56)
Their swarming and tempo are causing real difficulty to Udinese.
It was, however, a real difficulty getting the police to take it seriously".
This is something that Mitt Romney seems to have a real difficulty with, as he continues making insensitive comments such as, "I like being able to fire people who provide services to me," and how his wife Anne "drives a couple of Cadillacs".
"This shows a real difficulty in dialogue and cooperation," the commission said.
We can identify lots of ideas for a framework but without adequate resources that causes a real difficulty".
The difficulty with personality disorder is that they have a real difficulty with a core identity or feeling of self.
We agree there is a real difficulty in defining the orthology of cnidarian Hox genes.
Nevertheless, I made myself stop, and I pulled up alongside her — still thinking of this person on the road as a woman, possibly a woman in real difficulty — just to check, at least, that she was all right.
"They have real difficulty trying to tell the difference in quality changes and safety spoilage.
The real difficulty is to predict their vicinity regions (consensus sequences) and more distant sites.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com