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The phrase "a real difference in" is correct and usable in written English.
It can be used to highlight a significant or meaningful distinction between two or more things.
Example: "There is a real difference in the quality of service provided by the two companies."
Alternatives: "a significant difference in" or "a notable difference in".
Exact(60)
It'll make a real difference in leasing.
"There's a real difference in styles emerging here.
Could mindfulness training for police officers have made a real difference in Ferguson or New York?
Each year, individuals and teams make a real difference in student life at MIT.
Your time and talent can make a real difference in people's lives.
I feel like I'm making a real difference in people's lives". Learn more.
She dedicated her life to making a real difference in the world.
You have the knowledge, skills, energy, and network to make a real difference in the world.
"He can make a real difference in the final eight games".
The rationale is sound: it takes fundamental breakthroughs to make a real difference in medicine.
And with this hopeful approach, we can make a real difference in people's lives".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com