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The phrase "a real difference between" is correct and usable in written English.
You can use it when discussing distinctions or contrasts between two or more items, concepts, or situations.
Example: "There is a real difference between working in an office and working remotely."
Alternatives: "a significant difference between" or "a genuine difference between".
Exact(60)
The reasons could be different interpretations of patient records or a real difference between the groups.
Is there a real difference between analytic psychotherapy and psychoanalysis?
Is there a real difference between sugar and corn syrup?
Cruz said the question illustrated "a real difference between us" on foreign policy.
I think there's a real difference between being bossy and being a leader.
"There's a real difference between him and Al Gore, and he relishes that," Mr. Shays added.
"There is a real difference between Gore and the Republican ticket".
"There is a real difference between managing and leading," she once said.
That difference was statistically significant, meaning it was not due to chance but to a real difference between the drugs.
There is a real difference between watching something which lasts 12 hours and something which lasts 24.
And he needs to show them that there is a real difference between Labour and the Tory party.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com