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The phrase "a real breakthrough" is correct and usable in written English.
It is typically used to describe a sudden and successful solution to a difficult problem or challenge. For example, "The new cancer treatment was a real breakthrough, curing patients that had previously been considered untreatable."
Exact(60)
"It's a real breakthrough," he said.
So what would be a real breakthrough?
"It was a real breakthrough," Alford says.
"This is a real breakthrough," said Feunteun.
"This was a real breakthrough," he said.
This movie thing is a real breakthrough.
"I think the Volt is a real breakthrough.
Death and inglory in Chechnya A real breakthrough?
It could be a real breakthrough for Asian cinema.
IT WAS not by any stretch of the imagination a real breakthrough.
But a real breakthrough at a Vice-Presidential summit would be unseemly.
More suggestions(19)
a serious breakthrough
a real success
a considerable breakthrough
a genuine breakthrough
a practical breakthrough
a fundamental breakthrough
a tangible breakthrough
a true breakthrough
a substantive breakthrough
a substantial breakthrough
a definite breakthrough
a real face
a real crisis
a real chance
a key breakthrough
a real impact
a real smile
a real estate
a real pro
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com