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Patients with underlying diseases such as asthma and chronic urticaria are at much higher risk, and up to 35% of patients will have a reaction upon exposure to NSAIDs.
For example, patients who have had an allergic reaction to penicillin have a fourfold to sixfold increased risk for a reaction upon exposure to other β-lactams [ 4].
When genetic or genomic associations are identified for a particular drug adverse event, such that an individual with a certain genotype has a significantly increased risk to develop such a reaction upon drug exposure, this result can immediately be useful to patients and physicians in a clinic; assuming of course that an alternative treatment is available.
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Monocytes from septic patients are mainly characterized by a decreased capacity to mount a proinflammatory reaction upon a secondary bacterial challenge and by impairment in antigen presentation capacity, most probably due to the lowered expression of major histocompatibility complex class II molecules.
Indeed, monocyte deactivation is thought to be responsible for the impairment in antigen presentation and the decreased capacity to mount a proinflammatory reaction upon a secondary bacterial challenge [133].
Indeed, monocyte deactivation is thought to be responsible for the impairment in antigen presentation and the decreased capacity to mount a proinflammatory reaction upon a secondary bacterial challenge [ 133].
Such enzymes, whose ability to catalyze a reaction depends upon molecules other than their substrates (the ones upon which they act to form a product), are said to be under allosteric control.
The assignment of samples to particular roles within a reaction act upon the calculations, as the equivalents are always calculated with respect to the given amount of starting material which is set to 1 per default.
When elevated temperature causes widespread protein aggregation, Hsp104 becomes critical for survival by disaggregating proteins in a reaction dependent upon Hsp70 and Hsp40 [20].
Stanley Kubrick's final film, a haunting psychosexual drama, drew a divisive reaction upon release but offered much to admire, not least Kidman's intriguing turn that hits its peak in her confessional scene above.
It is assumed that this reaction is specific for cells expressing an active cytochrome c oxidase, because strains lacking such an enzyme usually show only a weak reaction upon exposure to TMPD, which can be used as electron donor instead of cytochrome c by terminal oxidases [50].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com